Melatonin is secreted by the pineal gland, with levels peaking at night to help maintain our tissues in a youthful state. Melatonin declines significantly with age, as the pineal gland becomes calcified. This melatonin formulation is for those who need the fastest possible sleep-inducing action. By dissolving in the mouth, melatonin goes directly to the brain and bypasses the liver where much of orally ingested melatonin can be metabolized (in some people) before it reaches the brain. Melatonin most effectively supports nighttime sleep when taken 15 minutes before bedtime.